EXPERIMENTAL PHYSIOLOGY LABORATORY (EPhyL)

WEB Experimental Physiology Laboratory

PRINCIPAL INVESTIGATORS


Fredi Cifuentes

Associate Professor


José L. Vega

Assistant Professor

RESEARCH
The EPhyL is dedicated to research and teaching in the area of physiology. Fredi Cifuentes is dedicated to understandings about people's use of plants and their biological effects and scientist José L. Vega s...

WEB Experimental Physiology Laboratory

PRINCIPAL INVESTIGATORS


Fredi Cifuentes

Associate Professor


José L. Vega

Assistant Professor

RESEARCH
The EPhyL is dedicated to research and teaching in the area of physiology. Fredi Cifuentes is dedicated to understandings about people's use of plants and their biological effects and scientist José L. Vega studies role of hemichannels in pathogenesis of infections. We use different experimental approaches including cell culture, myography and Langendorff system.

PROJECTS
1. Role of cardiac hemichannels in Trypanosoma cruzi infection. FONDECYT Nº11130013-CONICYT (2013-2016).
2. Development of therapeutic products for treatment of high blood pressure from herbaceous species of Chilean flora. FONDEF DO7I1113-CONICYT (2011-2012).

PUBLICATIONS
2016
Cifuentes F, Paredes A, Palacios J, Muñoz F, Carvajal L, Nwokocha CR, Morales G. Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice: Chronotropicand negative inotropic effect, a nifedipine-like action. J Ethnopharmacol. 179:367-74.
Cifuentes F, Palacios J, Nwokocha CR. Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide. Cardiovasc Toxicol. 16:79-88.
2015
Riquelme MA, Cea LA, Vega JL, Puebla C, Vargas AA, Shoji KF, Subiabre M, Sáez JC. Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation. Front Cell Dev Biol 3:25.
2014
Falk L, Dang-Lawson M, Vega JL, Pournia F, Choi K, Jang C, Naus CC, Matsuuchi L. Mutations of Cx43 that affect B cell spreading in response to BCR signaling. Biol Open. 2014;3:185-94.
Le HT, Sin WC, Lozinsky S, Bechberger J, Vega JL, Guo XQ, Sáez JC, Naus CC. Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. J Biol Chem 289:1345-54.
2013
Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of gap junctions and hemichannels in parasitic infections. Biomed Res Int 2013:589130.
Kozoriz MG, Lai S, Vega JL, Sáez JC, Sin WC, Bechberger JF, Naus CC. Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia. Neuropharmacology 75:549-56.
Riquelme MA, Cea LA, Vega JL, Boric MP, Monyer H, Bennett MV, Frank M, Willecke K, Sáez JC. The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. Neuropharmacology 75:594-603.
Palacios J, Vega JL, Paredes A, Cifuentes F. Effect of phenylephrine and endothelium on vasomotion in rat aorta involves potassium uptake. J Physiol Sci 63:103-11.
2012
Cea LA, Riquelme MA, Cisterna BA, Puebla C, Vega JL, Rovegno M, Sáez JC. Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy. J Membr Biol 245:423-36.
Palacios J, Roman D, Cifuentes F. Exposure to low level of arsenic and lead in drinking water from Antofagasta city induces gender differences in glucose homeostasis in rats. Biol Trace Elem Res 148:224-31.
Schalper KA, Riquelme MA, Brañes MC, Martínez AD, Vega JL, Berthoud VM, Bennett MV, Sáez JC. Modulation of gap junction channels and hemichannels by growth factors. Mol Biosyst 8:685-98

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EXPERIMENTAL PHYSIOLOGY LABORATORY (EPhyL) IA Instituto Antofagasta - Chile